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Targeting protein prenylation for cancer therapy
Protein farnesylation and geranylgeranylation, together referred to as prenylation, are lipid post-translational modifications that are required for the transforming activity of many oncogenic proteins, including some RAS family members. This observation prompted the development of inhibitors of far...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4037130/ https://ncbi.nlm.nih.gov/pubmed/22020205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrc3151 |
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