The Human Enzyme That Converts Dietary Provitamin A Carotenoids to Vitamin A Is a Dioxygenase

β-Carotene 15–15′-oxygenase (BCO1) catalyzes the oxidative cleavage of dietary provitamin A carotenoids to retinal (vitamin A aldehyde). Aldehydes readily exchange their carbonyl oxygen with water, making oxygen labeling experiments challenging. BCO1 has been thought to be a monooxygenase, incorpora...

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Autores principales: dela Seña, Carlo, Riedl, Kenneth M., Narayanasamy, Sureshbabu, Curley, Robert W., Schwartz, Steven J., Harrison, Earl H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Enzymology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036370/
https://ncbi.nlm.nih.gov/pubmed/24668807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.557710
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