Normal Activation of Discoidin Domain Receptor 1 Mutants with Disulfide Cross-links, Insertions, or Deletions in the Extracellular Juxtamembrane Region: MECHANISTIC IMPLICATIONS

The discoidin domain receptors, DDR1 and DDR2, are receptor tyrosine kinases that are activated by collagen. DDR activation does not appear to occur by the common mechanism of ligand-induced receptor dimerization: the DDRs form stable noncovalent dimers in the absence of ligand, and ligand-induced a...

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Main Authors: Xu, Huifang, Abe, Takemoto, Liu, Justin K. H., Zalivina, Irina, Hohenester, Erhard, Leitinger, Birgit
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036362/
https://ncbi.nlm.nih.gov/pubmed/24671415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.536144
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