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Vinculin Regulates Osteoclast Function

Osteoclastic bone resorption depends upon the cell's ability to organize its cytoskeleton. Because vinculin (VCL) is an actin-binding protein, we asked whether it participates in skeletal degradation. Thus, we mated VCL(fl/fl) mice with those expressing cathepsin K-Cre (CtsK-VCL) to delete the...

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Autors principals: Fukunaga, Tomohiro, Zou, Wei, Warren, Julia T., Teitelbaum, Steven L.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036361/
https://ncbi.nlm.nih.gov/pubmed/24675074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.550731
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