N-terminal Proline-rich Domain Is Required for Scrambling Activity of Human Phospholipid Scramblases

Human phospholipid scramblase 1 (hPLSCR1), a type II integral class membrane protein, is known to mediate bidirectional scrambling of phospholipids in a Ca(2+)-dependent manner. hPLSCR2, a homolog of hPLSCR1 that lacks N-terminal proline-rich domain (PRD), did not show scramblase activity. We attrib...

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Autori principali: Rayala, Sarika, Francis, Vincent G., Sivagnanam, Ulaganathan, Gummadi, Sathyanarayana N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2014
Soggetti:
Membrane Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036332/
https://ncbi.nlm.nih.gov/pubmed/24648509
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.522953
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