Computational and Experimental Studies on β-Sheet Breakers Targeting Aβ(1–40) Fibrils

In this work we present and compare the results of extensive molecular dynamics simulations of model systems comprising an Aβ(1–40) peptide in water in interaction with short peptides (β-sheet breakers) mimicking the 17–21 region of the Aβ(1–40) sequence. Various systems differing in the customized...

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Detalhes bibliográficos
Main Authors: Minicozzi, Velia, Chiaraluce, Roberta, Consalvi, Valerio, Giordano, Cesare, Narcisi, Claudia, Punzi, Pasqualina, Rossi, Giancarlo C., Morante, Silvia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Molecular Bases of Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036262/
https://ncbi.nlm.nih.gov/pubmed/24584938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.537472
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