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Disulfide Cross-linking of Transport and Trimerization Domains of a Neuronal Glutamate Transporter Restricts the Role of the Substrate to the Gating of the Anion Conductance

Excitatory amino acid transporters remove synaptically released glutamate and maintain its concentrations below neurotoxic levels. EAATs also mediate a thermodynamically uncoupled substrate-gated anion conductance that may modulate cell excitability. A structure of an archeal homologue, which reflec...

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Autors principals: Shabaneh, Mustafa, Rosental, Noa, Kanner, Baruch I.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036256/
https://ncbi.nlm.nih.gov/pubmed/24584931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.550277
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