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Disulfide Cross-linking of Transport and Trimerization Domains of a Neuronal Glutamate Transporter Restricts the Role of the Substrate to the Gating of the Anion Conductance

Excitatory amino acid transporters remove synaptically released glutamate and maintain its concentrations below neurotoxic levels. EAATs also mediate a thermodynamically uncoupled substrate-gated anion conductance that may modulate cell excitability. A structure of an archeal homologue, which reflec...

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Bibliografske podrobnosti
Main Authors: Shabaneh, Mustafa, Rosental, Noa, Kanner, Baruch I.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036256/
https://ncbi.nlm.nih.gov/pubmed/24584931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.550277
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