The DDN Catalytic Motif Is Required for Metnase Functions in Non-homologous End Joining (NHEJ) Repair and Replication Restart

Metnase (or SETMAR) arose from a chimeric fusion of the Hsmar1 transposase downstream of a protein methylase in anthropoid primates. Although the Metnase transposase domain has been largely conserved, its catalytic motif (DDN) differs from the DDD motif of related transposases, which may be importan...

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Bibliographische Detailangaben
Hauptverfasser: Kim, Hyun-Suk, Chen, Qiujia, Kim, Sung-Kyung, Nickoloff, Jac A., Hromas, Robert, Georgiadis, Millie M., Lee, Suk-Hee
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2014
Schlagworte:
DNA and Chromosomes
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4036204/
https://ncbi.nlm.nih.gov/pubmed/24573677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.533216
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