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PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context
There has been increasing interest in the use of isoform-selective inhibitors of phosphatidylinositide-3-kinase (PI3K) in cancer therapy. Using conditional deletion of the p110 catalytic isoforms of PI3K to predict sensitivity of cancer types to such inhibitors, we and others have demonstrated that...
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| Hauptverfasser: | , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4035990/ https://ncbi.nlm.nih.gov/pubmed/24737887 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323004111 |
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