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PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context

There has been increasing interest in the use of isoform-selective inhibitors of phosphatidylinositide-3-kinase (PI3K) in cancer therapy. Using conditional deletion of the p110 catalytic isoforms of PI3K to predict sensitivity of cancer types to such inhibitors, we and others have demonstrated that...

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Detalles Bibliográficos
Main Authors: Schmit, Fabienne, Utermark, Tamara, Zhang, Sen, Wang, Qi, Von, Thanh, Roberts, Thomas M., Zhao, Jean J.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2014
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035990/
https://ncbi.nlm.nih.gov/pubmed/24737887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1323004111
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