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Measurement of histidine pK(a) values and tautomer populations in invisible protein states
The histidine imidazole side chain plays a critical role in protein function and stability. Its importance for catalysis is underscored by the fact that histidines are localized to active sites in ∼50% of all enzymes. NMR spectroscopy has become an important tool for studies of histidine side chains...
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| Autores principales: | , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
2014
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4035968/ https://ncbi.nlm.nih.gov/pubmed/24733918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400577111 |
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