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Stoichiometry and specific assembly of Best ion channels

Human Bestrophin 1 (hBest1) is a calcium-activated chloride channel that regulates neuronal excitability, synaptic activity, and retinal homeostasis. Mutations in hBest1 cause the autosomal-dominant Best macular dystrophy (BMD). Because hBest1 mutations cause BMD, but a knockout does not, we wondere...

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Autori principali: Bharill, Shashank, Fu, Zhu, Palty, Raz, Isacoff, Ehud Y.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035945/
https://ncbi.nlm.nih.gov/pubmed/24748110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400248111
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