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Initial steps of inactivation at the K(+) channel selectivity filter

K(+) efflux through K(+) channels can be controlled by C-type inactivation, which is thought to arise from a conformational change near the channel’s selectivity filter. Inactivation is modulated by ion binding near the selectivity filter; however, the molecular forces that initiate inactivation rem...

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Detalhes bibliográficos
Main Authors: Thomson, Andrew S., Heer, Florian T., Smith, Frank J., Hendron, Eunan, Bernèche, Simon, Rothberg, Brad S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035917/
https://ncbi.nlm.nih.gov/pubmed/24733889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1317573111
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