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Privileged Diazepine Compounds and their Emergence as Bromodomain Inhibitors
Chemical compounds built on a diazepine scaffold have recently emerged as potent inhibitors of the acetyl-lysine binding activity of bromodomain-containing proteins, which is required for gene transcriptional activation in cancer and inflammation. Not only have these chemical compounds validated bro...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4035449/ https://ncbi.nlm.nih.gov/pubmed/24746559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.03.004 |
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