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Privileged Diazepine Compounds and their Emergence as Bromodomain Inhibitors

Chemical compounds built on a diazepine scaffold have recently emerged as potent inhibitors of the acetyl-lysine binding activity of bromodomain-containing proteins, which is required for gene transcriptional activation in cancer and inflammation. Not only have these chemical compounds validated bro...

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Библиографические подробности
Главные авторы: Smith, Steven G., Sanchez, Roberto, Zhou, Ming-Ming
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035449/
https://ncbi.nlm.nih.gov/pubmed/24746559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2014.03.004
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