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BCNU-INDUCED GR2 DEFECT MEDIATES S-GLUTATHIONYLATION OF COMPLEX I AND RESPIRATORY UNCOUPLING IN MYOCARDIUM(†)
A deficiency of mitochondrial glutathione reductase (or GR2) is capable of adversely affecting the reduction of GSSG and increasing mitochondrial oxidative stress. BCNU [1, 3-bis (2-chloroethyl)-1-nitrosourea] is an anticancer agent and known inhibitor of cytosolic GR ex vivo and in vivo. Here we te...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4035428/ https://ncbi.nlm.nih.gov/pubmed/24704251 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2014.03.012 |
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