BCNU-INDUCED GR2 DEFECT MEDIATES S-GLUTATHIONYLATION OF COMPLEX I AND RESPIRATORY UNCOUPLING IN MYOCARDIUM(†)

A deficiency of mitochondrial glutathione reductase (or GR2) is capable of adversely affecting the reduction of GSSG and increasing mitochondrial oxidative stress. BCNU [1, 3-bis (2-chloroethyl)-1-nitrosourea] is an anticancer agent and known inhibitor of cytosolic GR ex vivo and in vivo. Here we te...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Kang, Patrick T., Chen, Chwen-Lih, Zen, Pei, Guarini, Giacinta, Chen, Yeong-Renn
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2014
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4035428/
https://ncbi.nlm.nih.gov/pubmed/24704251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2014.03.012
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