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Convection-Enhanced Delivery of AAV2-PrPshRNA in Prion-Infected Mice
Prion disease is caused by a single pathogenic protein (PrP(Sc)), an abnormal conformer of the normal cellular prion protein PrP(C). Depletion of PrP(C) in prion knockout mice makes them resistant to prion disease. Thus, gene silencing of the Prnp gene is a promising effective therapeutic approach....
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4035323/ https://ncbi.nlm.nih.gov/pubmed/24866748 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098496 |
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