Elementary tetrahelical protein design for diverse oxidoreductase functions

Emulating functions of natural enzymes in man-made constructs has proven challenging. Here we describe a man-made protein platform that reproduces many of the diverse functions of natural oxidoreductases without importing the complex and obscure interactions common to natural proteins. Our design is...

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Detalhes bibliográficos
Main Authors: Farid, Tammer A, Kodali, Goutham, Solomon, Lee A, Lichtenstein, Bruce R, Sheehan, Molly M, Fry, Bryan A, Bialas, Chris, Ennist, Nathan M, Siedlecki, Jessica A, Zhao, Zhenyu, Stetz, Matthew A, Valentine, Kathleen G, Anderson, J L Ross, Wand, A Joshua, Discher, Bohdana M, Moser, Christopher C, Dutton, P Leslie
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4034760/
https://ncbi.nlm.nih.gov/pubmed/24121554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.1362
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