Oxygen sufficiency controls TOP mRNA translation via the TSC-Rheb-mTOR pathway in a 4E-BP-independent manner

Cells encountering hypoxic stress conserve resources and energy by downregulating the protein synthesis. Here we demonstrate that one mechanism in this response is the translational repression of TOP mRNAs that encode components of the translational apparatus. This mode of regulation involves TSC an...

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Main Authors: Miloslavski, Rachel, Cohen, Elad, Avraham, Adam, Iluz, Yifat, Hayouka, Zvi, Kasir, Judith, Mudhasani, Rajini, Jones, Stephen N., Cybulski, Nadine, Rüegg, Markus A., Larsson, Ola, Gandin, Valentina, Rajakumar, Arjuna, Topisirovic, Ivan, Meyuhas, Oded
格式: Artigo
語言:Inglês
出版: Oxford University Press 2014
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4034726/
https://ncbi.nlm.nih.gov/pubmed/24627160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jmcb/mju008
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