Caspase-8 mediates caspase-1 processing and innate immune defense in response to bacterial blockade of NF-κB and MAPK signaling

Toll-like receptor signaling and subsequent activation of NF-κB– and MAPK-dependent genes during infection play an important role in antimicrobial host defense. The YopJ protein of pathogenic Yersinia species inhibits NF-κB and MAPK signaling, resulting in blockade of NF-κB–dependent cytokine produc...

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Main Authors: Philip, Naomi H., Dillon, Christopher P., Snyder, Annelise G., Fitzgerald, Patrick, Wynosky-Dolfi, Meghan A., Zwack, Erin E., Hu, Baofeng, Fitzgerald, Louise, Mauldin, Elizabeth A., Copenhaver, Alan M., Shin, Sunny, Wei, Lei, Parker, Matthew, Zhang, Jinghui, Oberst, Andrew, Green, Douglas R., Brodsky, Igor E.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2014
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4034241/
https://ncbi.nlm.nih.gov/pubmed/24799700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1403252111
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