Evolution of the primate trypanolytic factor APOL1

ApolipoproteinL1 (APOL1) protects humans and some primates against several African trypanosomes. APOL1 genetic variants strongly associated with kidney disease in African Americans have additional trypanolytic activity against Trypanosoma brucei rhodesiense, the cause of acute African sleeping sickn...

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Autori principali: Thomson, Russell, Genovese, Giulio, Canon, Chelsea, Kovacsics, Daniella, Higgins, Matthew K., Carrington, Mark, Winkler, Cheryl A., Kopp, Jeffrey, Rotimi, Charles, Adeyemo, Adebowale, Doumatey, Ayo, Ayodo, George, Alper, Seth L., Pollak, Martin R., Friedman, David J., Raper, Jayne
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2014
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PNAS Plus
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4034216/
https://ncbi.nlm.nih.gov/pubmed/24808134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400699111
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