Synthesis and evaluation of [(11)C]PyrATP-1, a novel radiotracer for PET imaging of glycogen synthase kinase-3β (GSK-3β)

INTRODUCTION: The dysfunction of glycogen synthase kinase-3β(GSK-3β) has been implicated in a number of diseases, including Alzheimer’s disease. The ability to non-invasively quantify GSK-3βactivity in vivo is therefore of critical importance, and this work is focused upon development of inhibitors...

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Bibliographic Details
Main Authors: Cole, Erin L., Shao, Xia, Sherman, Phillip, Quesada, Carole, Fawaz, Maria V., Desmond, Timothy J., Scott, Peter J. H.
Format: Artigo
Language:Inglês
Published: 2014
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4034144/
https://ncbi.nlm.nih.gov/pubmed/24768148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2014.03.025
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