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Synthesis and evaluation of [(11)C]PyrATP-1, a novel radiotracer for PET imaging of glycogen synthase kinase-3β (GSK-3β)
INTRODUCTION: The dysfunction of glycogen synthase kinase-3β(GSK-3β) has been implicated in a number of diseases, including Alzheimer’s disease. The ability to non-invasively quantify GSK-3βactivity in vivo is therefore of critical importance, and this work is focused upon development of inhibitors...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4034144/ https://ncbi.nlm.nih.gov/pubmed/24768148 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nucmedbio.2014.03.025 |
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