PRKAR1A gene analysis and protein kinase A activity in endometrial tumors

BACKGROUND: PRKAR1A codes for the type 1a regulatory subunit (R1α) of the cAMP-dependent protein kinase A (PKA), an enzyme with an important role in cell cycle regulation and proliferation. PKA dyregulation has been found in various tumors and PRKAR1A-inactivating mutations have been reported in mos...

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Hauptverfasser: Tsigginou, A., Bimpaki, E., Nesterova, M., Horvath, A., Boikos, S., Lyssikatos, C., Papageorgiou, C., Dimitrakakis, C., Rodolakis, A., Stratakis, C.A., Antsaklis, A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4034123/
https://ncbi.nlm.nih.gov/pubmed/22461635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1530/ERC-11-0328
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