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Acetaminophen Reactive Intermediates Target Hepatic Thioredoxin Reductase
[Image: see text] Acetaminophen (APAP) is metabolized in the liver to N-acetyl-p-benzoquinone imine (NAPQI), an electrophilic metabolite known to bind liver proteins resulting in hepatotoxicity. Mammalian thioredoxin reductase (TrxR) is a cellular antioxidant containing selenocysteine (Sec) in its C...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Chemical
Society
2014
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4033643/ https://ncbi.nlm.nih.gov/pubmed/24661219 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx5000443 |
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