Standardization of RNA Chemical Mapping Experiments

[Image: see text] Chemical mapping experiments offer powerful information about RNA structure but currently involve ad hoc assumptions in data processing. We show that simple dilutions, referencing standards (GAGUA hairpins), and HiTRACE/MAPseeker analysis allow rigorous overmodification correction,...

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Bibliographic Details
Main Authors: Kladwang, Wipapat, Mann, Thomas H., Becka, Alex, Tian, Siqi, Kim, Hanjoo, Yoon, Sungroh, Das, Rhiju
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033625/
https://ncbi.nlm.nih.gov/pubmed/24766159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi5003426
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