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An efficient chemical synthesis of carboxylate-isostere analogs of daptomycin
Herein we report a direct and efficient method for the synthesis of four new carboxylate-isostere analogs of daptomycin. The side chain carboxylic acid moieties of the aspartic acids (Asp-3, Asp-7 and Asp-9) and β-methyl glutamic acid (MeGlu-12) were all converted into the corresponding carboxylate...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4033608/ https://ncbi.nlm.nih.gov/pubmed/23752953 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3ob40924d |
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