Nrf2 Deficiency Exaggerates Doxorubicin-Induced Cardiotoxicity and Cardiac Dysfunction

The anticancer therapy of doxorubicin (Dox) has been limited by its acute and chronic cardiotoxicity. In addition to a causative role of oxidative stress, autophagy appears to play an important role in the regulation of Dox-induced cardiotoxicity. However, the underlying mechanisms remain unclear. A...

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Main Authors: Li, Siying, Wang, Wenjuan, Niu, Ting, Wang, Hui, Li, Bin, Shao, Lei, Lai, Yimu, Li, Huanjie, Janicki, Joseph S., Wang, Xing Li, Tang, Dongqi, Cui, Taixing
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033424/
https://ncbi.nlm.nih.gov/pubmed/24895528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2014/748524
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