Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy

Diabetic nephropathy may occur, in part, as a result of intrarenal oxidative stress. NADPH oxidases comprise the only known dedicated reactive oxygen species (ROS)–forming enzyme family. In the rodent kidney, three isoforms of the catalytic subunit of NADPH oxidase are expressed (Nox1, Nox2, and Nox...

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Detaylı Bibliyografya
Asıl Yazarlar: Jha, Jay C., Gray, Stephen P., Barit, David, Okabe, Jun, El-Osta, Assam, Namikoshi, Tamehachi, Thallas-Bonke, Vicki, Wingler, Kirstin, Szyndralewiez, Cedric, Heitz, Freddy, Touyz, Rhian M., Cooper, Mark E., Schmidt, Harald H.H.W., Jandeleit-Dahm, Karin A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society of Nephrology 2014
Konular:
Basic Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033375/
https://ncbi.nlm.nih.gov/pubmed/24511132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013070810
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