Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy

Diabetic nephropathy may occur, in part, as a result of intrarenal oxidative stress. NADPH oxidases comprise the only known dedicated reactive oxygen species (ROS)–forming enzyme family. In the rodent kidney, three isoforms of the catalytic subunit of NADPH oxidase are expressed (Nox1, Nox2, and Nox...

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主要な著者: Jha, Jay C., Gray, Stephen P., Barit, David, Okabe, Jun, El-Osta, Assam, Namikoshi, Tamehachi, Thallas-Bonke, Vicki, Wingler, Kirstin, Szyndralewiez, Cedric, Heitz, Freddy, Touyz, Rhian M., Cooper, Mark E., Schmidt, Harald H.H.W., Jandeleit-Dahm, Karin A.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Nephrology 2014
主題:
Basic Research
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033375/
https://ncbi.nlm.nih.gov/pubmed/24511132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013070810
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