Genetic Targeting or Pharmacologic Inhibition of NADPH Oxidase Nox4 Provides Renoprotection in Long-Term Diabetic Nephropathy

Diabetic nephropathy may occur, in part, as a result of intrarenal oxidative stress. NADPH oxidases comprise the only known dedicated reactive oxygen species (ROS)–forming enzyme family. In the rodent kidney, three isoforms of the catalytic subunit of NADPH oxidase are expressed (Nox1, Nox2, and Nox...

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Bibliografiska uppgifter
Huvudupphovsmän: Jha, Jay C., Gray, Stephen P., Barit, David, Okabe, Jun, El-Osta, Assam, Namikoshi, Tamehachi, Thallas-Bonke, Vicki, Wingler, Kirstin, Szyndralewiez, Cedric, Heitz, Freddy, Touyz, Rhian M., Cooper, Mark E., Schmidt, Harald H.H.W., Jandeleit-Dahm, Karin A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Nephrology 2014
Ämnen:
Basic Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033375/
https://ncbi.nlm.nih.gov/pubmed/24511132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2013070810
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