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T Cell Receptor Internalization from the Immunological Synapse is Mediated by TC21 and RhoG GTPase-Dependent Phagocytosis
The immunological synapse (IS) serves a dual role for sustained T cell receptor (TCR) signaling and for TCR downregulation. TC21 (Rras2) is a RRas subfamily GTPase that constitutively associates with the TCR and is implicated in tonic TCR signaling by activating phosphatidylinositol 3-kinase. In thi...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4033310/ https://ncbi.nlm.nih.gov/pubmed/21820331 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.06.003 |
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