T Cell Receptor Internalization from the Immunological Synapse is Mediated by TC21 and RhoG GTPase-Dependent Phagocytosis

The immunological synapse (IS) serves a dual role for sustained T cell receptor (TCR) signaling and for TCR downregulation. TC21 (Rras2) is a RRas subfamily GTPase that constitutively associates with the TCR and is implicated in tonic TCR signaling by activating phosphatidylinositol 3-kinase. In thi...

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Bibliografiske detaljer
Main Authors: Martínez-Martin, Nuria, Fernández-Arenas, Elena, Cemerski, Saso, Delgado, Pilar, Turner, Martin, Heuser, John, Irvine, Darrell J., Huang, Bonnie, Bustelo, Xosé R., Shaw, Andrey, Alarcón, Balbino
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033310/
https://ncbi.nlm.nih.gov/pubmed/21820331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2011.06.003
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