A non-inferiority trial of an attenuated combination strategy (‘COBRA-light’) compared to the original COBRA strategy: clinical results after 26 weeks

BACKGROUND: Early, intensive treatment of rheumatoid arthritis (RA) with the combination of (initially high dose) prednisolone, methotrexate and sulfasalazine (COBRA therapy) considerably lowers disease activity and suppresses radiological progression, but is infrequently prescribed in daily practic...

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Detalhes bibliográficos
Main Authors: den Uyl, Debby, ter Wee, Marieke, Boers, Maarten, Kerstens, Pit, Voskuyl, Alexandre, Nurmohamed, Mike, Raterman, Hennie, van Schaardenburg, Dirkjan, van Dillen, Nancy, Dijkmans, Ben, Lems, Willem
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2014
Assuntos:
Clinical and Epidemiological Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4033113/
https://ncbi.nlm.nih.gov/pubmed/23606682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2012-202818
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