CD4+CD25+FoxP3+ Regulatory Tregs inhibit fibrocyte recruitment and fibrosis via suppression of FGF-9 production in the TGF-β1 exposed murine lung

Pulmonary fibrosis is a difficult to treat, often fatal disease whose pathogenesis involves dysregulated TGF-β1 signaling. CD4+CD25+FoxP3+ Regulatory T cells (“Tregs”) exert important effects on host tolerance and arise from naïve CD4+ lymphocytes in response to TGF-β1. However, the precise contribu...

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Detalhes bibliográficos
Main Authors: Peng, Xueyan, Moore, Meagan W., Peng, Hong, Sun, Huanxing, Gan, Ye, Homer, Robert J., Herzog, Erica L.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032896/
https://ncbi.nlm.nih.gov/pubmed/24904415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2014.00080
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