Molecular mechanisms of nutlin-3 involve acetylation of p53, histones and heat shock proteins in acute myeloid leukemia

BACKGROUND: The small-molecule MDM2 antagonist nutlin-3 has proved to be an effective p53 activating therapeutic compound in several preclinical cancer models, including acute myeloid leukemia (AML). We and others have previously reported a vigorous acetylation of the p53 protein by nutlin-treatment...

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Hauptverfasser: Haaland, Ingvild, Opsahl, Jill A, Berven, Frode S, Reikvam, Håkon, Fredly, Hanne K, Haugse, Ragnhild, Thiede, Bernd, McCormack, Emmet, Lain, Sonia, Bruserud, Øystein, Gjertsen, Bjørn Tore
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032636/
https://ncbi.nlm.nih.gov/pubmed/24885082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-116
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