Intradiscal injection of simvastatin results in radiologic, histologic, and genetic evidence of disc regeneration in a rat model of degenerative disc disease

BACKGROUND CONTEXT: A large percentage of back pain can be attributed to degeneration of the intervertebral disc (IVD). Bone morphogenetic protein-2 (BMP-2) is known to play an important role in chondrogenesis of the IVD. Simvastatin is known to up-regulate expression of BMP-2. Thus, we hypothesized...

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Main Authors: Than, Khoi D., Rahman, Shayan U., Wang, Lin, Khan, Adam, Kyere, Kwaku A., Than, Tracey T., Miyata, Yoshinari, Park, Yoon-Shin, La Marca, Frank, Kim, Hyungjin M., Zhang, Huina, Park, Paul, Lin, Chia-Ying
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032598/
https://ncbi.nlm.nih.gov/pubmed/24291703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.spinee.2013.11.034
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