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Discriminating binding mechanisms of an intrinsically disordered protein via a multi-state coarse-grained model
Many proteins undergo a conformational transition upon binding to their cognate binding partner, with intrinsically disordered proteins (IDPs) providing an extreme example in which a folding transition occurs. However, it is often not clear whether this occurs via an “induced fit” or “conformational...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
AIP Publishing LLC
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4032430/ https://ncbi.nlm.nih.gov/pubmed/24811666 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.4873710 |
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