Differential Synaptic and Extrasynaptic Glutamate-Receptor Alterations in Striatal Medium-Sized Spiny Neurons of Aged YAC128 Huntington’s Disease Mice

Huntington’s disease (HD) is a late-onset, slowly progressing neurodegenerative disorder caused by an expansion of glutamine repeats. The YAC128 mouse model has been widely used to study the progression of HD symptoms, but little is known about synaptic alterations in very old animals. The present e...

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Bibliographic Details
Main Authors: Botelho, Eliã P., Wang, Elizabeth, Chen, Jane Y., Holley, Sandra, Andre, Veronique, Cepeda, Carlos, Levine, Michael S.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
HD Models
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032384/
https://ncbi.nlm.nih.gov/pubmed/24894506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/currents.hd.34957c4f8bd7cb1f5ec47381dfc811c3
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