Sequence artefacts in a prospective series of formalin-fixed tumours tested for mutations in hotspot regions by massively parallel sequencing

BACKGROUND: Clinical specimens undergoing diagnostic molecular pathology testing are fixed in formalin due to the necessity for detailed morphological assessment. However, formalin fixation can cause major issues with molecular testing, as it causes DNA damage such as fragmentation and non-reproduci...

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Detalhes bibliográficos
Main Authors: Wong, Stephen Q, Li, Jason, Tan, Angela Y-C, Vedururu, Ravikiran, Pang, Jia-Min B, Do, Hongdo, Ellul, Jason, Doig, Ken, Bell, Anthony, MacArthur, Grant A, Fox, Stephen B, Thomas, David M, Fellowes, Andrew, Parisot, John P, Dobrovic, Alexander
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032349/
https://ncbi.nlm.nih.gov/pubmed/24885028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1755-8794-7-23
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