Metformin Induces Apoptosis and Cell Cycle Arrest Mediated by Oxidative Stress, AMPK and FOXO3a in MCF-7 Breast Cancer Cells

Recent studies have demonstrated that the anti-diabetic drug, metformin, can exhibit direct antitumoral effects, or can indirectly decrease tumor proliferation by improving insulin sensitivity. Despite these recent advances, the underlying molecular mechanisms involved in decreasing tumor formation...

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Detalhes bibliográficos
Main Authors: Queiroz, Eveline A. I. F., Puukila, Stephanie, Eichler, Rosangela, Sampaio, Sandra C., Forsyth, Heidi L., Lees, Simon J., Barbosa, Aneli M., Dekker, Robert F. H., Fortes, Zuleica B., Khaper, Neelam
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032293/
https://ncbi.nlm.nih.gov/pubmed/24858012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0098207
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