Combined Treatment of MCF-7 Cells with AICAR and Methotrexate, Arrests Cell Cycle and Reverses Warburg Metabolism through AMP-Activated Protein Kinase (AMPK) and FOXO1

Cancer cells are characterized by metabolic alterations, namely, depressed mitochondrial oxidation, enhanced glycolysis and pentose phosphate shunt flux to support rapid cell growth, which is called the Warburg effect. In our study we assessed the metabolic consequences of a joint treatment of MCF-7...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Fodor, Tamás, Szántó, Magdolna, Abdul-Rahman, Omar, Nagy, Lilla, Dér, Ádám, Kiss, Borbála, Bai, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4769015/
https://ncbi.nlm.nih.gov/pubmed/26919657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150232
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