Second Generation Steroidal 4-Aminoquinolines Are Potent, Dual-Target Inhibitors of the Botulinum Neurotoxin Serotype A Metalloprotease and P. falciparum Malaria

[Image: see text] Significantly more potent second generation 4-amino-7-chloroquinoline (4,7-ACQ) based inhibitors of the botulinum neurotoxin serotype A (BoNT/A) light chain were synthesized. Introducing an amino group at the C(3) position of the cholate component markedly increased potency (IC(50)...

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Détails bibliographiques
Auteurs principaux: Videnović, Milica, Opsenica, Dejan M., Burnett, James C., Gomba, Laura, Nuss, Jonathan E., Selaković, Života, Konstantinović, Jelena, Krstić, Maja, Šegan, Sandra, Zlatović, Mario, Sciotti, Richard J., Bavari, Sina, Šolaja, Bogdan A.
Format: Artigo
Langue:Inglês
Publié: American Chemical Society 2014
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032193/
https://ncbi.nlm.nih.gov/pubmed/24742203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm500033r
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