New Steroidal 4-Aminoquinolines Antagonize Botulinum Neurotoxin Serotype A in Mouse Embryonic Stem Cell Derived Motor Neurons in Post-intoxication Model

The synthesis and inhibitory potencies against botulinum neurotoxin serotype A light chain (BoNT/A LC) using in vitro HPLC based enzymatic assay for various steroidal, benzothiophene, thiophene and adamantane 4 aminoquinoline derivatives is described. In addition, the compounds were evaluated for th...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Konstantinović, Jelena, Kiris, Erkan, Kota, Krishna P., Tonos, Johanny Kugelman, Videnović, Milica, Cazares, Lisa H., Jovanović, Nataša Terzić, Verbić, Tatjana Ž., Andjelković, Boban, Duplantier, Allen J., Bavari, Sina, Šolaja, Bogdan A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833296/
https://ncbi.nlm.nih.gov/pubmed/29385334
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01710
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