An Investigation of G-Quadruplex Structural Polymorphism in the Human Telomere Using a Combined Approach of Hydrodynamic Bead Modeling and Molecular Dynamics Simulation

[Image: see text] Guanine-rich oligonucleotides can adopt noncanonical tertiary structures known as G-quadruplexes, which can exist in different forms depending on experimental conditions. High-resolution structural methods, such as X-ray crystallography and NMR spectroscopy, have been of limited us...

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Bibliographic Details
Main Authors: Le, Huy T., Dean, William L., Buscaglia, Robert, Chaires, Jonathan B., Trent, John O.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2014
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032189/
https://ncbi.nlm.nih.gov/pubmed/24779348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp502213y
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