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An Investigation of G-Quadruplex Structural Polymorphism in the Human Telomere Using a Combined Approach of Hydrodynamic Bead Modeling and Molecular Dynamics Simulation

[Image: see text] Guanine-rich oligonucleotides can adopt noncanonical tertiary structures known as G-quadruplexes, which can exist in different forms depending on experimental conditions. High-resolution structural methods, such as X-ray crystallography and NMR spectroscopy, have been of limited us...

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Main Authors: Le, Huy T., Dean, William L., Buscaglia, Robert, Chaires, Jonathan B., Trent, John O.
格式: Artigo
語言:Inglês
出版: American Chemical Society 2014
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032189/
https://ncbi.nlm.nih.gov/pubmed/24779348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jp502213y
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