Uptake and transfection efficiency of PEGylated cationic liposome–DNA complexes with and without RGD-tagging

Steric stabilization of cationic liposome–DNA (CL–DNA) complexes is required for in vivo applications such as gene therapy. PEGylation (PEG: poly(ethylene glycol)) of CL–DNA complexes by addition of PEG2000-lipids yields sterically stabilized nanoparticles but strongly reduces their gene delivery ef...

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Détails bibliographiques
Auteurs principaux: Majzoub, Ramsey N., Chan, Chia-Ling, Ewert, Kai K., Silva, Bruno F. B., Liang, Keng S., Jacovetty, Erica L., Carragher, Bridget, Potter, Clinton S., Safinya, Cyrus R.
Format: Artigo
Langue:Inglês
Publié: 2014
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4032065/
https://ncbi.nlm.nih.gov/pubmed/24661552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2014.03.007
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