Endosomal Escape and Transfection Efficiency of PEGylated Cationic Lipid–DNA Complexes Prepared with an Acid-Labile PEG-Lipid

Cationic liposome–DNA (CL–DNA) complexes are being pursued as nonviral gene delivery systems for use in applications that include clinic trials. However, to compete with viral vectors for systemic delivery in vivo, their efficiencies and pharmacokinetics need to be improved. The addition of poly (et...

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Библиографические подробности
Главные авторы: Chan, Chia-Ling, Majzoub, Ramsey N., Shirazi, Rahau S., Ewert, Kai K., Chen, Yen-Ju, Liang, Keng S., Safinya, Cyrus R.
Формат: Artigo
Язык:Inglês
Опубликовано: 2012
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3337860/
https://ncbi.nlm.nih.gov/pubmed/22469293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2012.03.038
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