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Endosomal Escape and Transfection Efficiency of PEGylated Cationic Lipid–DNA Complexes Prepared with an Acid-Labile PEG-Lipid

Cationic liposome–DNA (CL–DNA) complexes are being pursued as nonviral gene delivery systems for use in applications that include clinic trials. However, to compete with viral vectors for systemic delivery in vivo, their efficiencies and pharmacokinetics need to be improved. The addition of poly (et...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Chan, Chia-Ling, Majzoub, Ramsey N., Shirazi, Rahau S., Ewert, Kai K., Chen, Yen-Ju, Liang, Keng S., Safinya, Cyrus R.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3337860/
https://ncbi.nlm.nih.gov/pubmed/22469293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2012.03.038
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