On the formation of 7-ketocholesterol from 7-dehydrocholesterol in patients with CTX and SLO

A new mechanism for formation of 7-ketocholesterol was recently described involving cytochrome P-450 (CYP)7A1-catalyzed conversion of 7-dehydrocholesterol into 7-ketocholesterol with cholesterol-7,8-epoxide as a side product. Some patients with cerebrotendinous xanthomatosis (CTX) and all patients w...

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Detalhes bibliográficos
Main Authors: Björkhem, Ingemar, Diczfalusy, Ulf, Lövgren-Sandblom, Anita, Starck, Lena, Jonsson, Monica, Tallman, Keri, Schirmer, Henrik, Ousager, Lilian Bomme, Crick, Peter J., Wang, Yuqin, Griffiths, William J., Guengerich, F. Peter
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Patient-Oriented and Epidemiological Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031947/
https://ncbi.nlm.nih.gov/pubmed/24771866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.P048603
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