Crystal Structures of GCN2 Protein Kinase C-terminal Domains Suggest Regulatory Differences in Yeast and Mammals

In response to amino acid starvation, GCN2 phosphorylation of eIF2 leads to repression of general translation and initiation of gene reprogramming that facilitates adaptation to nutrient stress. GCN2 is a multidomain protein with key regulatory domains that directly monitor uncharged tRNAs which acc...

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Hlavní autoři: He, Hongzhen, Singh, Isha, Wek, Sheree A., Dey, Souvik, Baird, Thomas D., Wek, Ronald C., Georgiadis, Millie M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2014
Témata:
Protein Structure and Folding
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031553/
https://ncbi.nlm.nih.gov/pubmed/24719324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.560789
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