Crystal Structures of GCN2 Protein Kinase C-terminal Domains Suggest Regulatory Differences in Yeast and Mammals

In response to amino acid starvation, GCN2 phosphorylation of eIF2 leads to repression of general translation and initiation of gene reprogramming that facilitates adaptation to nutrient stress. GCN2 is a multidomain protein with key regulatory domains that directly monitor uncharged tRNAs which acc...

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Bibliographic Details
Main Authors: He, Hongzhen, Singh, Isha, Wek, Sheree A., Dey, Souvik, Baird, Thomas D., Wek, Ronald C., Georgiadis, Millie M.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031553/
https://ncbi.nlm.nih.gov/pubmed/24719324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.560789
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