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Point Mutations in Dimerization Motifs of the Transmembrane Domain Stabilize Active or Inactive State of the EphA2 Receptor Tyrosine Kinase

The EphA2 receptor tyrosine kinase plays a central role in the regulation of cell adhesion and guidance in many human tissues. The activation of EphA2 occurs after proper dimerization/oligomerization in the plasma membrane, which occurs with the participation of extracellular and cytoplasmic domains...

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Bibliografski detalji
Glavni autori: Sharonov, George V., Bocharov, Eduard V., Kolosov, Peter M., Astapova, Maria V., Arseniev, Alexander S., Feofanov, Alexey V.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031544/
https://ncbi.nlm.nih.gov/pubmed/24733396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.558783
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