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The E3 Ubiquitin Protein Ligase HERC2 Modulates the Activity of Tumor Protein p53 by Regulating Its Oligomerization

The tumor suppressor p53 is a transcription factor that coordinates the cellular response to several kinds of stress. p53 inactivation is an important step in tumor progression. Oligomerization of p53 is critical for its posttranslational modification and its ability to regulate the transcription of...

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Detalhes bibliográficos
Main Authors: Cubillos-Rojas, Monica, Amair-Pinedo, Fabiola, Peiró-Jordán, Roser, Bartrons, Ramon, Ventura, Francesc, Rosa, Jose Luis
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4031533/
https://ncbi.nlm.nih.gov/pubmed/24722987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.527978
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